Ontology highlight
ABSTRACT:
SUBMITTER: Wang D
PROVIDER: S-EPMC6969186 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Wang Dongdong D Wu Huihui H Phua Soo Zeng Fiona SZF Yang Guangbao G Qi Lim Wei W Gu Long L Qian Cheng C Wang Haibao H Guo Zhen Z Chen Hongzhong H Zhao Yanli Y
Nature communications 20200117 1
Hypoxia of solid tumor compromises the therapeutic outcome of photodynamic therapy (PDT) that relies on localized O<sub>2</sub> molecules to produce highly cytotoxic singlet oxygen (<sup>1</sup>O<sub>2</sub>) species. Herein, we present a safe and versatile self-assembled PDT nanoagent, i.e., OxgeMCC-r single-atom enzyme (SAE), consisting of single-atom ruthenium as the active catalytic site anchored in a metal-organic framework Mn<sub>3</sub>[Co(CN)<sub>6</sub>]<sub>2</sub> with encapsulated ch ...[more]