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Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor.


ABSTRACT: Hypoxia of solid tumor compromises the therapeutic outcome of photodynamic therapy (PDT) that relies on localized O2 molecules to produce highly cytotoxic singlet oxygen (1O2) species. Herein, we present a safe and versatile self-assembled PDT nanoagent, i.e., OxgeMCC-r single-atom enzyme (SAE), consisting of single-atom ruthenium as the active catalytic site anchored in a metal-organic framework Mn3[Co(CN)6]2 with encapsulated chlorin e6 (Ce6), which serves as a catalase-like nanozyme for oxygen generation. Coordination-driven self-assembly of organic linkers and metal ions in the presence of a biocompatible polymer generates a nanoscale network that adaptively encapsulates Ce6. The resulted OxgeMCC-r SAE possesses well-defined morphology, uniform size distribution and high loading capacity. When conducting the in situ O2 generation through the reaction between endogenous H2O2 and single-atom Ru species of OxgeMCC-r SAE, the hypoxia in tumor microenvironment is relieved. Our study demonstrates a promising self-assembled nanozyme with highly efficient single-atom catalytic sites for cancer treatment.

SUBMITTER: Wang D 

PROVIDER: S-EPMC6969186 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor.

Wang Dongdong D   Wu Huihui H   Phua Soo Zeng Fiona SZF   Yang Guangbao G   Qi Lim Wei W   Gu Long L   Qian Cheng C   Wang Haibao H   Guo Zhen Z   Chen Hongzhong H   Zhao Yanli Y  

Nature communications 20200117 1


Hypoxia of solid tumor compromises the therapeutic outcome of photodynamic therapy (PDT) that relies on localized O<sub>2</sub> molecules to produce highly cytotoxic singlet oxygen (<sup>1</sup>O<sub>2</sub>) species. Herein, we present a safe and versatile self-assembled PDT nanoagent, i.e., OxgeMCC-r single-atom enzyme (SAE), consisting of single-atom ruthenium as the active catalytic site anchored in a metal-organic framework Mn<sub>3</sub>[Co(CN)<sub>6</sub>]<sub>2</sub> with encapsulated ch  ...[more]

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