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Development of brain networks for social functions: Confirmatory analyses in a large open source dataset.

ABSTRACT: Human observers show robust activity in distinct brain networks during movie-viewing. For example, scenes that emphasize characters' thoughts evoke activity in the "Theory of Mind" (ToM) network, whereas scenes that emphasize characters' bodily sensations evoke activity in the "Pain Matrix." A prior exploratory fMRI study used a naturalistic movie-viewing stimulus to study the developmental origins of this functional dissociation, and the links between cortical and cognitive changes in children's social development (Richardson et al., 2018). To replicate and extend this work, the current study utilized a large publicly available dataset (n = 241, ages 5-20 years) (Alexander et al., 2017) who viewed "The Present" (Frey, 2014) and completed a resting state scan (n = 200) while undergoing fMRI. This study provides confirmatory evidence that 1) ToM and pain networks are functionally dissociated early in development, 2) selectivity increases with age, and in ToM regions, with a behavioral index of social reasoning. Additionally, while inter-region correlations are similar when measured during the movie and at rest, only inter-region correlations measured during movie-viewing correlated with functional maturity. This study demonstrates the scientific benefits of open source data in developmental cognitive neuroscience, and provides insight into the relationship between functional and intrinsic properties of the developing brain.

SUBMITTER: Richardson H

PROVIDER: S-EPMC6969289 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Note: Data Use Restrictions: <ul> <li>The data must only be used for genetic research projects solely in the area of health-related social-network research.</li> </ul> This study compiles detailed information on family and social ties linked to participants in the offspring cohort of the Framingham Heart Study. The investigators took computerized information from self-report data used by the FHS for over 30 years to facilitate health exam scheduling. These tracking sheets asked participants to identify people close to them, which were assumed by the investigators to indicate a social tie. Individuals are listed as "egos" (if the ties are from their perspective) and/or "alters" (if they are linked as a friend or family members to one of the other participants). All egos were FHS offspring participants while alters could be FHS participants in any cohort or non-participants. This information was combined with internal FHS pedigree data on family ties to list family member alters (as well as the nature of their relationship). The resultant dataset therefore includes each ego-alter tie, the nature of their relationship and the start and end dates for their ties for each of seven waves for the offspring study. Due to privacy concerns, all exam dates for individuals are listed relative to the initial FHS exam date. The study investigators chose a random, confidential date, to which all initial exam dates are linked (by number of months from random date to initial exam date). With this information, researchers can have access to the temporal relationships among participants' exam dates while remaining unaware of the actual exam dates for individual participants. During each clinic exam cycle, the participants undergo a detailed examination including physical examination, medical history, laboratory testing, and electrocardiogram. Over the years, other tests (that may not be performed at every exam cycle) have included pulmonary function, lifestyle, physical function, cognitive function questionnaires, and various noninvasive cardiovascular tests including echocardiograms. This study involves phenotypic data from these exams including (when available) basic body measurements (height, weight, blood pressure), laboratory values (blood sugar levels, LDL levels), information on smoking and alcohol use, and tests of depression and cognitive functioning. Important links to apply for individual-level data <ol> <li><a href="http://dbgap.ncbi.nlm.nih.gov/aa/wga.cgi?view_pdf&stacc=phs000153.v3.p3" target="_blank">Data Use Certification Requirements (DUC)</a></li> <li><a href="GetPdf.cgi?id=phd001183.1" target="_blank">Instructions to Request Authorized Access</a></li> <li><a href="http://view.ncbi.nlm.nih.gov/dbgap-controlled" target="_blank">Apply here for controlled access to individual level data</a></li> <li><a href="GetPdf.cgi?id=phd000317" target="_blank">Participant Protection Policy FAQ</a></li> </ol> In 1948, researchers recruited men and women from the town of Framingham, Massachusetts, beginning the first round of extensive physical examinations and lifestyle interviews that would later be analyzed for common patterns related to CVD development. Initially, the Framingham Heart Study enrolled 5,209 men and women from the Framingham area who were between the ages of 28 and 62 years. Beginning in 1971, the Framingham Heart Study enrolled 5,124 men and women, who were either offspring of the original cohort or spouses of those offspring. In 2002, 4,095 third generation participants (men and women) were enrolled.

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Development of brain networks for social functions: Confirmatory analyses in a large open source dataset.

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