Pet Ownership Protects Against Recurrence of Clostridioides difficile Infection.

ABSTRACT:

Background

Clostridioides difficile infection (CDI) is the leading cause of antibiotic-associated and health care-associated diarrhea in humans. Recurrent CDI (R-CDI) occurs in ~20%-30% of patients with CDI and results in increased morbidity, mortality, and hospital costs. Genomic analyses have shown overlap of C. difficile isolates from animals and people, suggesting that a zoonotic reservoir may contribute to recurrence. The objective of this study was to determine whether pet ownership is a risk factor for recurrence of CDI.

Methods

We conducted a case-control study among patients with recurrent CDI (cases; n = 86) and patients with nonrecurrent CDI (controls; n = 146). Multivariable logistic regression modeling was used to determine the association between

SUBMITTER: Redding LE 

PROVIDER: S-EPMC6969483 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature