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ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC6969538 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Zhou Jianfu J Panaitiu Alexandra E AE Grigoryan Gevorg G
Proceedings of the National Academy of Sciences of the United States of America 20191231 2
Current state-of-the-art approaches to computational protein design (CPD) aim to capture the determinants of structure from physical principles. While this has led to many successful designs, it does have strong limitations associated with inaccuracies in physical modeling, such that a reliable general solution to CPD has yet to be found. Here, we propose a design framework-one based on identifying and applying patterns of sequence-structure compatibility found in known proteins, rather than app ...[more]