Ontology highlight
ABSTRACT:
SUBMITTER: Newman JH
PROVIDER: S-EPMC6969546 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Newman Jenna H JH Chesson C Brent CB Herzog Nora L NL Bommareddy Praveen K PK Aspromonte Salvatore M SM Pepe Russell R Estupinian Ricardo R Aboelatta Mones M MM Buddhadev Stuti S Tarabichi Saeed S Lee Michael M Li Shengguo S Medina Daniel J DJ Giurini Eileena F EF Gupta Kajal H KH Guevara-Aleman Gabriel G Rossi Marco M Nowicki Christina C Abed Abdulkareem A Goldufsky Josef W JW Broucek Joseph R JR Redondo Raquel E RE Rotter David D Jhawar Sachin R SR Wang Shang-Jui SJ Kohlhapp Frederick J FJ Kaufman Howard L HL Thomas Paul G PG Gupta Vineet V Kuzel Timothy M TM Reiser Jochen J Paras Joyce J Kane Michael P MP Singer Eric A EA Malhotra Jyoti J Denzin Lisa K LK Sant'Angelo Derek B DB Rabson Arnold B AB Lee Leonard Y LY Lasfar Ahmed A Langenfeld John J Schenkel Jason M JM Fidler Mary Jo MJ Ruiz Emily S ES Marzo Amanda L AL Rudra Jai S JS Silk Ann W AW Zloza Andrew A
Proceedings of the National Academy of Sciences of the United States of America 20191230 2
Reprogramming the tumor microenvironment to increase immune-mediated responses is currently of intense interest. Patients with immune-infiltrated "hot" tumors demonstrate higher treatment response rates and improved survival. However, only the minority of tumors are hot, and a limited proportion of patients benefit from immunotherapies. Innovative approaches that make tumors hot can have immediate impact particularly if they repurpose drugs with additional cancer-unrelated benefits. The seasonal ...[more]