Dataset Information

Gene mutation profiling in Chinese colorectal cancer patients and its association with clinicopathological characteristics and prognosis.

ABSTRACT: BACKGROUND:Gene mutations may play an important role in the development, response to treatment and prognosis of colorectal cancer (CRC). This retrospective study aimed to investigate the mutation profiling of Chinese patients with CRC, and its correlation with clinicopathological features and prognosis. METHODS:This study included 1190 Chinese CRC patients who were diagnosed between May 1998 and December 2018 and received clinical genetic testing. The OncoCarta Panel was used to test a total of 238 possible mutations in 19 common oncogenes. RESULTS:Five hundred and eighty-two (48.9%) cases were detected with gene mutations. Of the 582 cases, there were 111 cases (19.7%) with two concurrent mutations, and six cases (1.0%) with three concurrent mutations. KRAS was the most common gene mutation that occurred in all cases (429, 36.1%), followed by PIK3CA (121, 10.2%), NRAS (47, 3.9%), BRAF (35, 2.9%), HRAS (11, 0.9%) and epidermal growth factor receptor (EGFR) (11, 0.9%). AKT1, KIT, FGFR1, FGFR3, FLT3, CDK, ERBB2, ABL1, MET, RET and PDGFRA mutations were also detected in several cases. When it came to prognosis, we found that KRAS/NRAS/PIK3CA/BRAF mutation was not associated with prognosis. But BRAF mutation was associated with poor prognosis in patients who accepted anti-EGFR therapy. CONCLUSIONS:The molecular testing offered the clinical data and mutation profile of Chinese CRC patients. The information of these mutated genes may help to find out the correlation between mutated genes and the development or prognosis of CRC.

SUBMITTER: Ye ZL

PROVIDER: S-EPMC6970031 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Gene mutation profiling in Chinese colorectal cancer patients and its association with clinicopathological characteristics and prognosis.

Ye Zu-Lu ZL Qiu Miao-Zhen MZ Tang Tao T Wang Fang F Zhou Yi-Xin YX Lei Meng-Jie MJ Guan Wen-Long WL He Cai-Yun CY

Cancer medicine 20191128 2

<h4>Background</h4>Gene mutations may play an important role in the development, response to treatment and prognosis of colorectal cancer (CRC). This retrospective study aimed to investigate the mutation profiling of Chinese patients with CRC, and its correlation with clinicopathological features and prognosis.<h4>Methods</h4>This study included 1190 Chinese CRC patients who were diagnosed between May 1998 and December 2018 and received clinical genetic testing. The OncoCarta Panel was used to t ...[more]

PMID: 31782259

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Dataset Information

Gene mutation profiling in Chinese colorectal cancer patients and its association with clinicopathological characteristics and prognosis.

Publications

Gene mutation profiling in Chinese colorectal cancer patients and its association with clinicopathological characteristics and prognosis.

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