Dataset Information

Radiomics based on ¹⁸ F-FDG PET/CT could differentiate breast carcinoma from breast lymphoma using machine-learning approach: A preliminary study.

ABSTRACT:

Purpose

Our study assessed the ability ¹⁸ F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) radiomics to differentiate breast carcinoma from breast lymphoma using machine-learning approach.

Methods

Sixty-five breast nodules from 44 patients diagnosed as breast carcinoma or breast lymphoma were included. Standardized uptake value (SUV) and radiomic features from CT and PET images were extracted using local image features extraction software. Six discriminative models including PETa (based on clinical, SUV and radiomic features from PET images), PETb (SUV and radiomic features from PET images), PETc (radiomic features only from PET images), CTa (clinical and radiomic features from CT images), CTb (radiomic features only from CT images), and SUV model were generated using least absolute shrinkage and selection operator method and linear discriminant analysis. The areas under the receiver operating characteristic curve (AUCs), accuracy, sensitivity, and specificity were calculated to evaluate the discriminative ability of these models.

Results

PETa and CTa models showed the best ability to differentiation in training and validation group (AUCs of 0.867 and 0.806 for PETa model, AUCs of 0.891 and 0.759 for CTa model, respectively).

Conclusion

Models based on clinical, SUV, and radiomic features of ¹⁸ F-FDG PET/CT images could accurately discriminate breast carcinoma from breast lymphoma.

SUBMITTER: Ou X

PROVIDER: S-EPMC6970046 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Publications

Radiomics based on <sup>18</sup> F-FDG PET/CT could differentiate breast carcinoma from breast lymphoma using machine-learning approach: A preliminary study.

Ou Xuejin X Zhang Jing J Wang Jian J Pang Fuwen F Wang Yongsheng Y Wei Xiawei X Ma Xuelei X

Cancer medicine 20191125 2

<h4>Purpose</h4>Our study assessed the ability <sup>18</sup> F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) radiomics to differentiate breast carcinoma from breast lymphoma using machine-learning approach.<h4>Methods</h4>Sixty-five breast nodules from 44 patients diagnosed as breast carcinoma or breast lymphoma were included. Standardized uptake value (SUV) and radiomic features from CT and PET images were extracted using local image features extraction so ...[more]

PMID: 31769230

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Project description:BackgroundThere is evidence that metabolic disease burden in lymphoma influences patient outcome. However, the impact of disease severity on the cardiovascular system is unknown.ObjectivesThe aim of this study was to examine whether lymphoma is associated with arterial inflammation by investigating the relationship between disease metabolic burden and arterial fluorodeoxyglucose (FDG) uptake.MethodsSixty-two chemotherapy-naïve patients with active Hodgkin's or non-Hodgkin's lymphoma were matched (2:1) to individual control groups of lymphoma patients previously treated and free of active disease. All groups underwent 18F-FDG position emission tomography-computed tomography imaging. Disease severity was quantified by metabolic tumor volume (MTV) and total lesion glycolysis corresponding to standardized uptake values (SUVs) ≥41% or ≥2.5 of the maximum SUV within lymphoma regions, and aortic FDG uptake was quantified through the target-to-background ratio (TBR). Inflammatory and disease severity biomarkers were also measured.ResultsMTV and total lesion glycolysis measurements were significantly correlated with inflammatory and disease biomarkers. Aortic TBR was higher in patients with active non-Hodgkin's lymphoma compared with control subjects (median difference 0.51; 95% confidence interval [CI]: 0.28 to 0.78; p < 0.001). Similarly, patients with active Hodgkin's lymphoma had higher values of aortic TBR compared with control subjects (median difference 0.31; 95% CI: 0.15 to 0.49; p < 0.001). In addition, aortic TBR was modestly increased in patients with stage III to IV disease compared with those with stage I to II disease (median aortic TBR: 2.23 [interquartile range: 2.01 to 2.54] vs. 2.06 [interquartile range: 1.83 to 2.27; p = 0.050). In multivariable analysis, aortic FDG uptake and MTV≥2.5 values were independently associated (β = 0.425; 95% CI: 0.189 to 0.662; p = 0.001; R2 = 0.208), as were aortic FDG uptake and MTV≥41% (β = 0.407; 95% CI: 0.167 to 0.649, p = 0.001; R2 = 0.191).ConclusionsAortic wall FDG uptake is related with disease severity indicative of a possible vascular effect of lymphoma. This work highlights a new potential role of molecular imaging in cardio-oncology for evaluating disease severity and its consequences on the vasculature.

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Project description:PurposeTo determine if quantitative features extracted from pretherapy fluorine 18 fluorodeoxyglucose (18F-FDG) PET/CT estimate prognosis in patients with locally advanced cervical cancer treated with chemoradiotherapy.Materials and methodsIn this retrospective study, PET/CT images and outcomes were curated from 154 patients with locally advanced cervical cancer, who underwent chemoradiotherapy from two institutions between March 2008 and June 2016, separated into independent training (n = 78; mean age, 51 years ± 13 [standard deviation]) and testing (n = 76; mean age, 50 years ± 10) cohorts. Radiomic features were extracted from PET, CT, and habitat (subregions with different metabolic characteristics) images that were derived by fusing PET and CT images. Parsimonious sets of these features were identified by the least absolute shrinkage and selection operator analysis and used to generate predictive radiomics signatures for progression-free survival (PFS) and overall survival (OS) estimation. Prognostic validation of the radiomic signatures as independent prognostic markers was performed using multivariable Cox regression, which was expressed as nomograms, together with other clinical risk factors.ResultsThe radiomics nomograms constructed with T stage, lymph node status, and radiomics signatures resulted in significantly better performance for the estimation of PFS (Harrell concordance index [C-index], 0.85 for training and 0.82 for test) and OS (C-index, 0.86 for training and 0.82 for test) compared with International Federation of Gynecology and Obstetrics staging system (C-index for PFS, 0.70 for training [P = .001] and 0.70 for test [P = .002]; C-index for OS, 0.73 for training [P < .001] and 0.70 for test [P < .001]), respectively.ConclusionPrognostic models were generated and validated from quantitative analysis of 18F-FDG PET/CT habitat images and clinical data, and may have the potential to identify the patients who need more aggressive treatment in clinical practice, pending further validation with larger prospective cohorts.Supplemental material is available for this article.© RSNA, 2020.

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Dataset Information

Radiomics based on ¹⁸ F-FDG PET/CT could differentiate breast carcinoma from breast lymphoma using machine-learning approach: A preliminary study.

Purpose

Methods

Results

Conclusion

Publications

Radiomics based on <sup>18</sup> F-FDG PET/CT could differentiate breast carcinoma from breast lymphoma using machine-learning approach: A preliminary study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Radiomics based on 18 F-FDG PET/CT could differentiate breast carcinoma from breast lymphoma using machine-learning approach: A preliminary study.

Purpose

Methods

Results

Conclusion

Publications

Radiomics based on <sup>18</sup> F-FDG PET/CT could differentiate breast carcinoma from breast lymphoma using machine-learning approach: A preliminary study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Radiomics based on ¹⁸ F-FDG PET/CT could differentiate breast carcinoma from breast lymphoma using machine-learning approach: A preliminary study.