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The serum concentration of ?CGRP is novel marker for type 1 diabetes.

ABSTRACT: Objective:Dysregulation of neuropeptides, such as calcitonin gene-related peptide (CGRP) is thought to play significant roles in diabetes. In the present study, we investigated the importance of beta-calcitonin gene related peptide (?CGRP, CALCB) in the development of type 1 diabetes (T1D). Methods:There were fifty-eight patients with T1D and 320 age and gender-matched healthy controls in Chinese Han population were included, the genotypes of CALCB were analyzed by direct sequencing and the clinicopathologic parameters of patients were also evaluated. Results:Among the SNPs genotyped, the C allele of CALCB_rs3829220 T (c.224G + 846) and rs382922 C (c.224G + 848) were positively associated with T1D (OR = 2.67 and 3.42, respectively). Serum ?CGRP of patients is 1.58 times higher compare to normal control. Immunohistochemistry analysis revealed ?CGRP expression in the infiltrating lymphocytes of pancreas from T1D mice as compared to normal control. Conclusion:Our findings indicate that the presence of ?CGRP is a probable molecular basis for the initial events triggered in T1D.

SUBMITTER: Chen Y

PROVIDER: S-EPMC6970168 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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The serum concentration of βCGRP is novel marker for type 1 diabetes.

Chen Yong Y Lin Yunfeng Y Wang Jingwen J Guo Xinxin X Guo Yujia Y Dong Feng F Gao Feng F Liu Qicai Q

Heliyon 20200116 1

<h4>Objective</h4>Dysregulation of neuropeptides, such as calcitonin gene-related peptide (CGRP) is thought to play significant roles in diabetes. In the present study, we investigated the importance of beta-calcitonin gene related peptide (βCGRP, <i>CALCB</i>) in the development of type 1 diabetes (T1D).<h4>Methods</h4>There were fifty-eight patients with T1D and 320 age and gender-matched healthy controls in Chinese Han population were included, the genotypes of <i>CALCB</i> were analyzed by d ...[more]

PMID: 31989054

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Project description:INTRODUCTION: Asthmatic inflammation is responsible for vital features of the disease, including bronchial hyperresponsiveness (BHR). At present we do not have precise markers for monitoring asthmatic inflammation. C-reactive protein (CRP), a marker of systemic inflammation, seemed to be a factor which could also reflect the level of asthmatic inflammation expressed by BHR. Therefore the relationship between CRP concentration and BHR was evaluated. MATERIALS AND METHODS: One hundred and two patients entered the study. A skin prick test with a broad spectrum of common aeroallergens as well as baseline spirometry and a histamine bronchoprovocation test were performed in each subject. Blood samples for high-sensitivity CRP (hsCRP) measurement were taken before the bronchial challenge tests. RESULTS: Serum hsCRP concentrations ranged from 0.20 to 14.5 mg/l (median: 1.2 mg/l, 25-75% quartiles: 0.6-2.4). Positive skin prick tests were found in 26 subjects. Bronchial hyperresponsiveness was confirmed in 42 patients (first subgroup), while 60 subjects did not demonstrate BHR (second subgroup). Among the patients with BHR, asthma was diagnosed in 33 cases and Corrao syndrome in 9. In both subgroups, serum hsCRP concentrations had similar levels (median: 1.4 mg/l, 25-75% quartiles: 0.8-2.4 and median: 0.9 mg/l, 25-75% quartiles: 0.5-2.8, respectively; p=0.297). There was no statistically significant correlation (r = -0.163, p = 0.302) between serum hsCRP concentration and the level of BHR expressed as the 20% provocative concentration for histamine. In addition, hsCRP serum concentration, after adjustment for age, atopy, body mass index, and gender, was not a significant predictor of positive histamine bronchoprovocation test results (p = 0.22, CONCLUSIONS: Serum hsCRP concentration is not a good marker of BHR, which is mainly dependent on asthmatic inflammation and is measured during bronchial challenge with histamine. This finding is important for interpreting and discussing results obtained from epidemiological and population-based studies on relationships between either CRP concentration and BHR or local and systemic inflammation.

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The serum concentration of ?CGRP is novel marker for type 1 diabetes.

Publications

The serum concentration of βCGRP is novel marker for type 1 diabetes.

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