Ontology highlight
ABSTRACT:
SUBMITTER: Wanner MJ
PROVIDER: S-EPMC6970265 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Wanner Martin J MJ Zuidinga Ed E Tromp Dorette S DS Vilím Jan J Jørgensen Steen Ingemann SI van Maarseveen Jan H JH
The Journal of organic chemistry 20191230 2
The neurotransmitter metabolite 3,4-dihydroxy-phenylglycolaldehyde (dopegal) damages neurons and the myocardium by protein cross-linking, resulting in conglomerations and cell death. We investigated this process on a synthetic scale, leading to the discovery of an Amadori-type rearrangement of dopegal in the reaction with several amino acids and neuropeptides. This alkylation also occurs with neurotransmitters, suggesting an influence of dopegal on neurochemical processes. The rearrangement occu ...[more]