Ontology highlight
ABSTRACT:
SUBMITTER: Lu Z
PROVIDER: S-EPMC6970533 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Lu Zhiwei Z Xie Yuhua Y Huang Huanwei H Jiang Kaiju K Zhou Bin B Wang Fengchao F Chen Ting T
eLife 20200103
Metabolites are major biological parameters sensed by many cell types in vivo, whether they function as signaling mediators of SC and niche cross talk to regulate tissue regeneration is largely unknown. We show here that deletion of the Notch pathway co-factor RBP-J specifically in mouse HFSCs triggers adjacent McSCs to precociously differentiate in their shared niche. Transcriptome screen and in vivo functional studies revealed that the elevated level of retinoic acid (RA) caused by de-repressi ...[more]