Ontology highlight
ABSTRACT:
SUBMITTER: Schanoski AS
PROVIDER: S-EPMC6971054 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Frontiers in immunology 20200114
Granzyme A (GzmA) is secreted by cytotoxic lymphocytes and has traditionally been viewed as a mediator of cell death. However, a growing body of data suggests the physiological role of GzmA is promotion of inflammation. Here, we show that GzmA is significantly elevated in the sera of chikungunya virus (CHIKV) patients and that GzmA levels correlated with viral loads and disease scores in these patients. Serum GzmA levels were also elevated in CHIKV mouse models, with NK cells the likely source. ...[more]