Ontology highlight
ABSTRACT:
SUBMITTER: Huang T
PROVIDER: S-EPMC6971064 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Cell death & disease 20200120 1
As the foundation of male fertility, spermatogenesis is a complicated and highly controlled process. YTHDF2 plays regulatory roles in biological processes through accelerating the degradation of target mRNAs. However, the function of YTHDF2 in spermatogenesis remains elusive. Here, we knocked out Ythdf2 in mouse spermatogonia via CRISPR/Cas9, and found that depletion of Ythdf2 mainly downregulated the expression of matrix metallopeptidase (MMPs), thus affecting cell adhesion and proliferation. m ...[more]