Ontology highlight
ABSTRACT:
SUBMITTER: Navarra G
PROVIDER: S-EPMC6971108 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Navarra Giovanna G Pagano Cristina C Pacelli Roberto R Crescenzi Elvira E Longobardi Elena E Gazzerro Patrizia P Fiore Donatella D Pastorino Olga O Pentimalli Francesca F Laezza Chiara C Bifulco Maurizio M
Frontiers in oncology 20200114
Glioblastoma is among the most common malignant brain tumors and has a dismal prognosis due to the poor response to therapeutic regimens such as ionizing radiation and DNA-alkylating agents. In our study, we investigated the radiosensitizing activity of the N<sup>6</sup>-isopentenyladenosine (iPA), an naturally modified adenosine harboring an isopenenyl moiety, which shows antiproliferative effects on glioblastoma cell lines. We observed that co-treatment with ionizing radiation and iPA at micro ...[more]