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High-normal PaCO2 values might be associated with worse outcome in patients with subarachnoid hemorrhage - a retrospective cohort study.

ABSTRACT: BACKGROUND:While both hypercapnia and hypocapnia are harmful in patients with subarachnoid hemorrhage (SAH), it is unknown whether high-normal PaCO2 values are better than low-normal values. We hypothesized that high-normal PaCO2 values have more detrimental than beneficial effects on outcome. METHODS:Consecutive patients with aneurysmal subarachnoid hemorrhage (aSAH) requiring mechanical ventilation treated in a tertiary care university hospital were retrospectively analyzed regarding the influence of PaCO2 on favorable outcome, defined as modified Rankin scale score?

SUBMITTER: Reiff T 

PROVIDER: S-EPMC6972024 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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High-normal P<sub>a</sub>CO<sub>2</sub> values might be associated with worse outcome in patients with subarachnoid hemorrhage - a retrospective cohort study.

Reiff Tilman T   Barthel Oliver O   Schönenberger Silvia S   Mundiyanapurath Sibu S  

BMC neurology 20200120 1

<h4>Background</h4>While both hypercapnia and hypocapnia are harmful in patients with subarachnoid hemorrhage (SAH), it is unknown whether high-normal P<sub>a</sub>CO<sub>2</sub> values are better than low-normal values. We hypothesized that high-normal P<sub>a</sub>CO<sub>2</sub> values have more detrimental than beneficial effects on outcome.<h4>Methods</h4>Consecutive patients with aneurysmal subarachnoid hemorrhage (aSAH) requiring mechanical ventilation treated in a tertiary care university  ...[more]

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