Ontology highlight
ABSTRACT:
SUBMITTER: Wiedenbeck E
PROVIDER: S-EPMC6972611 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20191106 52
The nucleation mechanism of crystals of small organic molecules, postulated based on computer simulations, still lacks experimental evidence. In this study we designed an experimental approach to monitor the early stages of the crystallization of ibuprofen as a model system for small organic molecules. Ibuprofen undergoes liquid-liquid phase separation prior to nucleation. The binodal and spinodal limits of the corresponding liquid-liquid miscibility gap were analyzed and confirmed. An increase ...[more]