Ontology highlight
ABSTRACT:
SUBMITTER: Rubini R
PROVIDER: S-EPMC6972700 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Rubini Rudy R Ivanov Ilya I Mayer Clemens C
Chemistry (Weinheim an der Bergstrasse, Germany) 20191118 70
Interfacing biocompatible, small-molecule catalysis with cellular metabolism promises a straightforward introduction of new function into organisms without the need for genetic manipulation. However, identifying and optimizing synthetic catalysts that perform new-to-nature transformations under conditions that support life is a cumbersome task. To enable the rapid discovery and fine-tuning of biocompatible catalysts, we describe a 96-well screening platform that couples the activity of synthetic ...[more]