Ontology highlight
ABSTRACT:
SUBMITTER: Nishikawa T
PROVIDER: S-EPMC6972756 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nishikawa Tomoki T Nagata Naoto N Shimakami Tetsuro T Shirakura Takashi T Matsui Chieko C Ni Yinhua Y Zhuge Fen F Xu Liang L Chen Guanliang G Nagashimada Mayumi M Yamashita Taro T Sakai Yoshio Y Yamashita Tatsuya T Mizukoshi Eishiro E Honda Masao M Kaneko Shuichi S Ota Tsuguhito T
Scientific reports 20200121 1
Hyperuricemia drives the development of nonalcoholic fatty liver disease (NAFLD). Pharmacological inhibition of xanthine oxidase (XO), a rate-limiting enzyme for uric acid (UA) production, has been demonstrated to improve hepatic steatosis in diet-induced obese mice. However, it remains unclear whether inhibition of XO improves nonalcoholic steatohepatitis (NASH), a more advanced form of NAFLD, in terms of both liver inflammation and fibrosis. Here, we investigated the effects of febuxostat and ...[more]