Ontology highlight
ABSTRACT:
SUBMITTER: Mohammad M
PROVIDER: S-EPMC6973266 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20191031 50
A highly convergent strategy for the synthesis of the natural product (-)-rubriflordilactone B, and the proposed structure of (-)-pseudo-rubriflordilactone B, is described. Late stage coupling of diynes containing the respective natural product FG rings with a common AB ring aldehyde precedes rhodium-catalyzed [2+2+2] alkyne cyclotrimerization to form the natural product skeleton, with the syntheses completed in just one further operation. This work resolves the uncertainty surrounding the ident ...[more]