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Cascade Cross-Coupling of Dienes: Photoredox and Nickel Dual Catalysis.

ABSTRACT: Chemical transformations based on cascade reactions have the potential to simplify the preparation of diverse and architecturally complex molecules dramatically. Herein, we disclose an unprecedented and efficient method for the cross-coupling of radical precursors, dienes, and electrophilic coupling partners via a photoredox- and nickel-enabled cascade cross-coupling process. The cascade reaction furnishes a diverse array of saturated carbo- and heterocyclic scaffolds, thus providing access to a quick gain in C-C bond saturation.

SUBMITTER: Huang L

PROVIDER: S-EPMC6973272 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Cascade Cross-Coupling of Dienes: Photoredox and Nickel Dual Catalysis.

Huang Long L Zhu Chen C Yi Liang L Yue Huifeng H Kancherla Rajesh R Rueping Magnus M

Angewandte Chemie (International ed. in English) 20191128 1

Chemical transformations based on cascade reactions have the potential to simplify the preparation of diverse and architecturally complex molecules dramatically. Herein, we disclose an unprecedented and efficient method for the cross-coupling of radical precursors, dienes, and electrophilic coupling partners via a photoredox- and nickel-enabled cascade cross-coupling process. The cascade reaction furnishes a diverse array of saturated carbo- and heterocyclic scaffolds, thus providing access to a ...[more]

PMID: 31778289

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