Meta-analysis and Mendelian randomization: A review.
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ABSTRACT:
SUBMITTER: Bowden J
PROVIDER: S-EPMC6973275 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Meta-analysis and Mendelian randomization: A review.
Bowden Jack J Holmes Michael V MV
Research synthesis methods 20190423 4
Mendelian randomization (MR) uses genetic variants as instrumental variables to infer whether a risk factor causally affects a health outcome. Meta-analysis has been used historically in MR to combine results from separate epidemiological studies, with each study using a small but select group of genetic variants. In recent years, it has been used to combine genome-wide association study (GWAS) summary data for large numbers of genetic variants. Heterogeneity among the causal estimates obtained ...[more]
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