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The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence.

ABSTRACT: Axon guidance molecules direct growing axons toward their targets, assembling the intricate wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC (deleted in colorectal cancer), has profound effects, in laboratory animals, on the adolescent expansion of mesocorticolimbic pathways, particularly dopamine. Now, a rapidly growing literature suggests that (1) these same alterations could occur in humans, and (2) genetic variants in Netrin-1 and DCC are associated with depression, schizophrenia, and substance use. Together, these findings provide compelling evidence that Netrin-1 and DCC influence mesocorticolimbic-related psychopathological states that emerge during adolescence.

SUBMITTER: Vosberg DE

PROVIDER: S-EPMC6974431 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence.

Vosberg Daniel E DE Leyton Marco M Flores Cecilia C

Molecular psychiatry 20191028 2

Axon guidance molecules direct growing axons toward their targets, assembling the intricate wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC (deleted in colorectal cancer), has profound effects, in laboratory animals, on the adolescent expansion of mesocorticolimbic pathways, particularly dopamine. Now, a rapidly growing literature suggests that (1) these same alterations could occur in humans, and (2) genetic variants in Netrin-1 and DCC are associated with ...[more]

PMID: 31659271

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