Ontology highlight
ABSTRACT:
SUBMITTER: Ekpenyong-Akiba AE
PROVIDER: S-EPMC6974713 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Ekpenyong-Akiba Akang E AE Poblocka Marta M Althubiti Mohammad M Rada Miran M Jurk Diana D Germano Sandra S Kocsis-Fodor Gabriella G Shi Yu Y Canales Juan J JJ Macip Salvador S
Aging cell 20191117 1
One of the hallmarks of aging is the progressive accumulation of senescent cells in organisms, which has been proposed to be a contributing factor to age-dependent organ dysfunction. We recently reported that Bruton's tyrosine kinase (BTK) is an upstream component of the p53 responses to DNA damage. BTK binds to and phosphorylates p53 and MDM2, which results in increased p53 activity. Consistent with this, blocking BTK impairs p53-induced senescence. This suggests that sustained BTK inhibition c ...[more]