Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6975268 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Zhang Ya Y Wu Xuefeng X Kai Yan Y Lee Chia-Han CH Cheng Fengdong F Li Yixuan Y Zhuang Yongbao Y Ghaemmaghami Javid J Chuang Kun-Han KH Liu Zhuo Z Meng Yunxiao Y Keswani Meghana M Gough Nancy R NR Wu Xiaojun X Zhu Wenge W Tzatsos Alexandros A Peng Weiqun W Seto Edward E Sotomayor Eduardo M EM Zheng Xiaoyan X
JCI insight 20191219 24
Clinical and preclinical studies show tissue-specific differences in tumorigenesis. Tissue specificity is controlled by differential gene expression. We prioritized genes that encode secreted proteins according to their preferential expression in normal lungs to identify candidates associated with lung cancer. Indeed, most of the lung-enriched genes identified in our analysis have known or suspected roles in lung cancer. We focused on the gene encoding neuron-derived neurotrophic factor (NDNF), ...[more]