Ontology highlight
ABSTRACT:
SUBMITTER: Zhang HY
PROVIDER: S-EPMC6975528 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Zhang Hong-Yan HY Liao Bo-Wei BW Xu Zhi-Sheng ZS Ran Yong Y Wang Dong-Peng DP Yang Yan Y Luo Wei-Wei WW Wang Yan-Yi YY
PLoS pathogens 20200122 1
Mediator of IRF3 activation (MITA, also known as stimulator of interferon genes, STING) senses the second messenger cyclic GMP-AMP (cGAMP) which is synthesized upon DNA virus infection and activates innate antiviral immune response. It has been demonstrated that the activity of MITA is delicately regulated by various post-translational modifications including polyubiquitination. In this study, we identified the deubiquitinating enzyme USP44 as a positive regulator of MITA. USP44 is recruited to ...[more]