Modulation of Structural Heterogeneity Controls Phytochrome Photoswitching.
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ABSTRACT:
SUBMITTER: Gustavsson E
PROVIDER: S-EPMC6976809 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Modulation of Structural Heterogeneity Controls Phytochrome Photoswitching.
Gustavsson Emil E Isaksson Linnéa L Persson Cecilia C Mayzel Maxim M Brath Ulrika U Vrhovac Lidija L Ihalainen Janne A JA Karlsson B Göran BG Orekhov Vladislav V Westenhoff Sebastian S
Biophysical journal 20191126 2
Phytochromes sense red/far-red light and control many biological processes in plants, fungi, and bacteria. Although the crystal structures of dark- and light-adapted states have been determined, the molecular mechanisms underlying photoactivation remain elusive. Here, we demonstrate that the conserved tongue region of the PHY domain of a 57-kDa photosensory module of Deinococcus radiodurans phytochrome changes from a structurally heterogeneous dark state to an ordered, light-activated state. The ...[more]
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