Ontology highlight
ABSTRACT:
SUBMITTER: Jessop F
PROVIDER: S-EPMC6977132 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Jessop Forrest F Buntyn Robert R Schwarz Benjamin B Wehrly Tara T Scott Dana D Bosio Catharine M CM
Infection and immunity 20200122 2
The mechanisms by which interferon gamma (IFN-γ) controls the replication of cytosolic pathogens independent of responses, such as the generation of reactive oxygen species/reactive nitrogen species (ROS/RNS), have not been fully elucidated. In the current study, we developed a model using <i>Francisella tularensis</i>, the causative agent of tularemia, in which pathways triggered by IFN-γ commonly associated with bacterial control were not required. Using this model, we demonstrated that IFN-γ- ...[more]