Virus-induced transposable element expression up-regulation in human and mouse host cells.
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ABSTRACT:
SUBMITTER: Macchietto MG
PROVIDER: S-EPMC6977392 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Virus-induced transposable element expression up-regulation in human and mouse host cells.
Macchietto Marissa G MG Langlois Ryan A RA Shen Steven S SS
Life science alliance 20200121 2
Virus-host cell interactions initiate a host cell-defensive response during virus infection. How transposable elements in the host cell respond to viral stress at the molecular level remains largely unclear. By reanalyzing next generation sequencing data sets from dozens of virus infection studies from the Gene Expression Omnibus database, we found that genome-wide transposon expression up-regulation in host cells occurs near antiviral response genes and exists in all studies regardless of virus ...[more]
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