Aging exacerbates neutrophil pathogenicity in ischemic stroke.
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ABSTRACT:
SUBMITTER: Roy-O'Reilly MA
PROVIDER: S-EPMC6977697 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Aging exacerbates neutrophil pathogenicity in ischemic stroke.
Roy-O'Reilly Meaghan A MA Ahnstedt Hilda H Spychala Monica S MS Munshi Yashasvee Y Aronowski Jaroslaw J Sansing Lauren H LH McCullough Louise D LD
Aging 20200112 1
Ischemic stroke is major cause of disability and mortality worldwide, and aging is strong risk factor for poor post-stroke outcome. Neutrophils traffic rapidly to the brain following ischemic stroke, and recent evidence has suggested that aging may alter neutrophil function after tissue injury. In this study, we hypothesize that aging enhances the pro-inflammatory function of neutrophils, directly contributing to the poorer outcomes seen in aging patients. We utilized demographic data and biolog ...[more]
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