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Incidence of Adverse Psychiatric Events During Treatment of Inflammatory Bowel Disease With Biologic Therapies: A Systematic Review.

ABSTRACT: We conducted a systematic review and a fixed-effects meta-analysis to determine whether incident adverse psychiatric events (APE) including depression, anxiety, psychosis, or suicide were associated with biologic therapy in IBD. Six randomized controlled trials and a cohort study met criteria, reporting an incidence of APE in 4,882 patients. The risk difference per 100 person-months of any APE with a biologic medication was 0.01 (95% confidence interval = 0.00-0.02). There was insufficient evidence available in randomized controlled trials to conclude that biologic therapy in IBD is associated with an increased incidence of APE.

SUBMITTER: Jain A

PROVIDER: S-EPMC6977711 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Incidence of Adverse Psychiatric Events During Treatment of Inflammatory Bowel Disease With Biologic Therapies: A Systematic Review.

Jain Avni A Marrie Ruth Ann RA Shafer Leigh Anne LA Graff Lesley A LA Patten Scott B SB El-Gabalawy Renée R Sareen Jitender J Bolton James M JM Fisk John D JD Bernstein Charles N CN

Crohn's & colitis 360 20191219 1

We conducted a systematic review and a fixed-effects meta-analysis to determine whether incident adverse psychiatric events (APE) including depression, anxiety, psychosis, or suicide were associated with biologic therapy in IBD. Six randomized controlled trials and a cohort study met criteria, reporting an incidence of APE in 4,882 patients. The risk difference per 100 person-months of any APE with a biologic medication was 0.01 (95% confidence interval = 0.00-0.02). There was insufficient evide ...[more]

PMID: 32003760

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| S-EPMC10869791 | biostudies-literature

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| S-EPMC8994033 | biostudies-literature

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| S-EPMC6751339 | biostudies-literature

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| S-EPMC4872064 | biostudies-other

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| S-EPMC9713632 | biostudies-literature

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