Ontology highlight
ABSTRACT:
SUBMITTER: Bettcher BM
PROVIDER: S-EPMC6977973 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Bettcher Brianne M BM Gross Alden L AL Gavett Brandon E BE Widaman Keith F KF Fletcher Evan E Dowling N Maritza NM Buckley Rachel F RF Arenaza-Urquijo Eider M EM Zahodne Laura B LB Hohman Timothy J TJ Vonk Jet M J JMJ Rentz Dorene M DM Mungas Dan D
Neurobiology of aging 20190821
Cognitive reserve is inherently a dynamic construct; however, traditional methods of estimating reserve have focused on static proxy variables. A recently proposed psychometric approach entails modeling reserve as residual cognition not explained by demographic and brain variables. In this study, we extended this approach to longitudinal measurement and examined how change in reserve relates to clinical outcomes in late life and influences the effect of brain atrophy on cognitive decline. Result ...[more]