Dataset Information
Portal hypertensive gastropathy is associated with iron deficiency anemia.
Ontology highlight
ABSTRACT: Background and aims
Portal hypertensive gastropathy (PHG) is common in patients with cirrhosis and may cause bleeding. This study systematically explored the independent impact of patient characteristics, portal hypertension and hepatic dysfunction on PHG severity and associated anemia.Methods
Patients with cirrhosis undergoing endoscopy were included in this retrospective analysis and PHG was endoscopically graded as absent, mild or severe. Clinical and laboratory parameters and hepatic venous pressure gradient (HVPG) were assessed with respect to an association with severity of PHG.Results
A total of 110 patients (mean age: 57 years, 69% male) with mostly alcoholic liver disease (49%) or viral hepatitis (30%) were included: 15 (13.6%) patients had no PHG, 59 (53.6%) had mild PHG, and 36 (32.7%) had severe PHG. Severe PHG was significantly associated with male sex (83.3% vs. 62.2% in no or mild PHG; p?=?0.024) and higher Child-Turcotte-Pugh (CTP) stage (CTP-C: 38.9% vs. 27.0% in no or mild PHG; p?=?0.030), while MELD was similar (p?=?0.253). Patients with severe PHG had significantly lower hemoglobin values (11.2?±?0.4?g/dL vs. 12.4?±?0.2?g/dL; p?=?0.008) and a higher prevalence of iron-deficiency anemia (IDA: 48.5% vs. 26.9%; p?=?0.032). Interestingly, HVPG was not significantly higher in severe PHG (median 20?mm?Hg) vs. mild PHG (19?mm?Hg) and no PHG (18?mm?Hg; p?=?0.252). On multivariate analysis, CTP score (odds ratio, OR: 1.25, 95% confidence interval, CI 1.02-1.53; p?=?0.033) was independently associated with severe PHG, while only a trend towards an independent association with IDA was observed (OR: 2.28, 95% CI 0.91-5.72; p?=?0.078).Conclusion
The CTP score but not HVPG or MELD were risk factors for severe PHG. Importantly, anemia and especially IDA are significantly more common in patients with severe PHG.
SUBMITTER: Simbrunner B
PROVIDER: S-EPMC6978296 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Portal hypertensive gastropathy is associated with iron deficiency anemia.
Wiener klinische Wochenschrift 20200107 1-2
<h4>Background and aims</h4>Portal hypertensive gastropathy (PHG) is common in patients with cirrhosis and may cause bleeding. This study systematically explored the independent impact of patient characteristics, portal hypertension and hepatic dysfunction on PHG severity and associated anemia.<h4>Methods</h4>Patients with cirrhosis undergoing endoscopy were included in this retrospective analysis and PHG was endoscopically graded as absent, mild or severe. Clinical and laboratory parameters and ...[more]
