Ontology highlight
ABSTRACT:
SUBMITTER: van der Zwan M
PROVIDER: S-EPMC6978297 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Drugs 20200101 1
Costimulation between T cells and antigen-presenting cells is essential for the regulation of an effective alloimmune response and is not targeted with the conventional immunosuppressive therapy after kidney transplantation. Costimulation blockade therapy with biologicals allows precise targeting of the immune response but without non-immune adverse events. Multiple costimulation blockade approaches have been developed that inhibit the alloimmune response in kidney transplant recipients with var ...[more]