ISOGO: Functional annotation of protein-coding splice variants.

ABSTRACT: The advent of RNA-seq technologies has switched the paradigm of genetic analysis from a genome to a transcriptome-based perspective. Alternative splicing generates functional diversity in genes, but the precise functions of many individual isoforms are yet to be elucidated. Gene Ontology was developed to annotate gene products according to their biological processes, molecular functions and cellular components. Despite a single gene may have several gene products, most annotations are not isoform-specific and do not distinguish the functions of the different proteins originated from a single gene. Several approaches have tried to automatically annotate ontologies at the isoform level, but this has shown to be a daunting task. We have developed ISOGO (ISOform + GO function imputation), a no

SUBMITTER: Ferrer-Bonsoms JA 

PROVIDER: S-EPMC6978412 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature