Ontology highlight
ABSTRACT:
SUBMITTER: Wilson DH
PROVIDER: S-EPMC6978415 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Wilson D H DH Jarman E J EJ Mellin R P RP Wilson M L ML Waddell S H SH Tsokkou P P Younger N T NT Raven A A Bhalla S R SR Noll A T R ATR Olde Damink S W SW Schaap F G FG Chen P P Bates D O DO Banales J M JM Dean C H CH Henderson D J DJ Sansom O J OJ Kendall T J TJ Boulter L L
Nature communications 20200123 1
The number of patients diagnosed with chronic bile duct disease is increasing and in most cases these diseases result in chronic ductular scarring, necessitating liver transplantation. The formation of ductular scaring affects liver function; however, scar-generating portal fibroblasts also provide important instructive signals to promote the proliferation and differentiation of biliary epithelial cells. Therefore, understanding whether we can reduce scar formation while maintaining a pro-regene ...[more]