Ontology highlight
ABSTRACT:
SUBMITTER: Yazaki P
PROVIDER: S-EPMC6978469 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Yazaki Paul P Lwin Thinzar T Minnix Megan M Li Lin L Sherman Anakim A Molnar Justin J Miller Aaron A Frankel Paul P Chea Junie J Poku Erasmus E Bowles Nicole N Hoffman Robert R Shively John J Bouvet Michael M
Journal of biomedical optics 20190601 6
Real-time intraoperative image-guided cancer surgery promises to improve oncologic outcomes. Tumor-specific antibodies conjugated with near-infrared (NIR) fluorophores have demonstrated the potential to enhance visualization of solid tumor margins and metastatic disease; however, multiple challenges remain, including improvement in probe development for clinical utility. We have developed an NIR-IR800 dye on a PEGylated linker (sidewinder) conjugated to the humanized anti-carcinoembryonic antige ...[more]