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Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer's disease.

ABSTRACT: While the link between amyloid ? (A?) accumulation and synaptic degradation in Alzheimer's disease (AD) is known, the consequences of this pathology on population coding remain unknown. We found that the entropy, a measure of the diversity of network firing patterns, was lower in the dorsal CA1 region in the APP/PS1 mouse model of A? pathology, relative to controls, thereby reducing the population's coding capacity. Our results reveal a network level signature of the deficits A? accumulation causes to the computations performed by neural circuits.

SUBMITTER: Chockanathan U

PROVIDER: S-EPMC6978514 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer's disease.

Chockanathan Udaysankar U Warner Emily J EJ Turpin Loel L O'Banion M Kerry MK Padmanabhan Krishnan K

Scientific reports 20200123 1

While the link between amyloid β (Aβ) accumulation and synaptic degradation in Alzheimer's disease (AD) is known, the consequences of this pathology on population coding remain unknown. We found that the entropy, a measure of the diversity of network firing patterns, was lower in the dorsal CA1 region in the APP/PS1 mouse model of Aβ pathology, relative to controls, thereby reducing the population's coding capacity. Our results reveal a network level signature of the deficits Aβ accumulation cau ...[more]

PMID: 31974405

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2022-11-03 | GSE216901 | GEO

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