Ontology highlight
ABSTRACT:
SUBMITTER: Corbet C
PROVIDER: S-EPMC6978517 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Corbet Cyril C Bastien Estelle E Santiago de Jesus Joao Pedro JP Dierge Emeline E Martherus Ruben R Vander Linden Catherine C Doix Bastien B Degavre Charline C Guilbaud Céline C Petit Laurenne L Michiels Carine C Dessy Chantal C Larondelle Yvan Y Feron Olivier O
Nature communications 20200123 1
Acidosis, a common characteristic of the tumor microenvironment, is associated with alterations in metabolic preferences of cancer cells and progression of the disease. Here we identify the TGF-β2 isoform at the interface between these observations. We document that acidic pH promotes autocrine TGF-β2 signaling, which in turn favors the formation of lipid droplets (LD) that represent energy stores readily available to support anoikis resistance and cancer cell invasiveness. We find that, in canc ...[more]