MiR-146a Plasma Levels Are Not Altered in Alzheimer's Disease but Correlate With Age and Illness Severity.
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ABSTRACT:
SUBMITTER: Maffioletti E
PROVIDER: S-EPMC6978630 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
miR-146a Plasma Levels Are Not Altered in Alzheimer's Disease but Correlate With Age and Illness Severity.
Maffioletti Elisabetta E Milanesi Elena E Ansari Abulaish A Zanetti Orazio O Galluzzi Samantha S Geroldi Cristina C Gennarelli Massimo M Bocchio-Chiavetto Luisella L
Frontiers in aging neuroscience 20200117
miR-146a is a microRNA (miRNA) involved in neuroinflammation and aging; alterations in its expression were described in Alzheimer's disease (AD). However, most of the studies conducted so far on this miRNA included a limited number of participants and produced contradictory results. We compared miR-146a levels in plasma from 33 AD patients vs. 28 age-matched non-affected controls (CTRL) through quantitative real-time polymerase chain reaction (qRT-PCR). No difference between the case and the con ...[more]
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