Ontology highlight
ABSTRACT:
SUBMITTER: Haseda Y
PROVIDER: S-EPMC6980563 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Haseda Yasunari Y Munakata Lisa L Meng Jie J Suzuki Ryo R Aoshi Taiki T
PloS one 20200124 1
For the induction of antigen-specific T-cell responses by vaccination, an appropriate immune adjuvant is required. Vaccine adjuvants generally provide two functions, namely, immune potentiator and delivery, and many adjuvants that can efficiently induce T-cell responses are known to have the combination of these two functions. In this study, we explored a cationic lipid DOTAP-based adjuvant. We found that the microfluidic preparation of DOTAP nanoparticles induced stronger CD4+ and CD8+ T-cell r ...[more]