Ontology highlight
ABSTRACT:
SUBMITTER: Marikawa Y
PROVIDER: S-EPMC6980740 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Marikawa Yusuke Y Chen Hong-Ru HR Menor Mark M Deng Youping Y Alarcon Vernadeth B VB
Reproductive toxicology (Elmsford, N.Y.) 20191108
Pluripotent stem cells recapitulate many aspects of embryogenesis in vitro. Here, we established a novel culture system to differentiate human embryonic stem cell aggregates (HESCA), and evaluated its utility for teratogenicity assessment. Culture of HESCA with modulators of developmental signals induced morphogenetic and molecular changes associated with differentiation of the paraxial mesoderm and neuroectoderm. To examine impact of teratogenic exposures on HESCA differentiation, 18 compounds ...[more]