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ABSTRACT:
SUBMITTER: Nazarian A
PROVIDER: S-EPMC6980752 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nazarian Alireza A Arbeev Konstantin G KG Kulminski Alexander M AM
Journal of applied genetics 20191121 1
The generalized linear mixed models (GLMMs) methodology is the standard framework for genome-wide association studies (GWAS) of complex diseases in family-based cohorts. Fitting GLMMs in very large cohorts, however, can be computationally demanding. Also, the modified versions of GLMM using faster algorithms may underperform, for instance when a single nucleotide polymorphism (SNP) is correlated with fixed-effects covariates. We investigated the extent to which disregarding family structure may ...[more]