Environmental and genetic determinants of plasmid mobility in pathogenic Escherichia coli.
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ABSTRACT:
SUBMITTER: Bethke JH
PROVIDER: S-EPMC6981087 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Environmental and genetic determinants of plasmid mobility in pathogenic <i>Escherichia coli</i>.
Bethke Jonathan H JH Davidovich Adam A Cheng Li L Lopatkin Allison J AJ Song Wenchen W Thaden Joshua T JT Fowler Vance G VG Xiao Minfeng M You Lingchong L
Science advances 20200124 4
Plasmids are key vehicles of horizontal gene transfer (HGT), mobilizing antibiotic resistance, virulence, and other traits among bacterial populations. The environmental and genetic forces that drive plasmid transfer are poorly understood, however, due to the lack of definitive quantification coupled with genomic analysis. Here, we integrate conjugative phenotype with plasmid genotype to provide quantitative analysis of HGT in clinical <i>Escherichia coli</i> pathogens. We find a substantial pro ...[more]
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