Ontology highlight
ABSTRACT:
SUBMITTER: Kielkowski P
PROVIDER: S-EPMC6981130 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Kielkowski Pavel P Buchsbaum Isabel Y IY Kirsch Volker C VC Bach Nina C NC Drukker Micha M Cappello Silvia S Sieber Stephan A SA
Nature communications 20200124 1
Posttranslational modification (PTM) of proteins represents an important cellular mechanism for controlling diverse functions such as signalling, localisation or protein-protein interactions. AMPylation (also termed adenylylation) has recently been discovered as a prevalent PTM for regulating protein activity. In human cells AMPylation has been exclusively studied with the FICD protein. Here we investigate the role of AMPylation in human neurogenesis by introducing a cell-permeable propargyl ade ...[more]