Ontology highlight
ABSTRACT:
SUBMITTER: Choi SY
PROVIDER: S-EPMC6981200 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Choi Sung Yong SY Bae Hosung H Jeong Sun-Hye SH Park Intae I Cho Hyunsoo H Hong Seon Pyo SP Lee Da-Hye DH Lee Choong-Kun CK Park Jin-Sung JS Suh Sang Heon SH Choi Jeongwoon J Yang Myung Jin MJ Jang Jeon Yeob JY Onder Lucas L Moon Jeong Hwan JH Jeong Han-Sin HS Adams Ralf H RH Kim Jin-Man JM Ludewig Burkhard B Song Joo-Hye JH Lim Dae-Sik DS Koh Gou Young GY
Nature communications 20200124 1
Fibroblastic reticular cells (FRCs) are immunologically specialized myofibroblasts of lymphoid organ, and FRC maturation is essential for structural and functional properties of lymph nodes (LNs). Here we show that YAP and TAZ (YAP/TAZ), the final effectors of Hippo signaling, regulate FRC commitment and maturation. Selective depletion of YAP/TAZ in FRCs impairs FRC growth and differentiation and compromises the structural organization of LNs, whereas hyperactivation of YAP/TAZ enhances myofibro ...[more]