Ontology highlight
ABSTRACT:
SUBMITTER: Wu CP
PROVIDER: S-EPMC6981391 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Wu Chung-Pu CP Lusvarghi Sabrina S Wang Jyun-Cheng JC Hsiao Sung-Han SH Huang Yang-Hui YH Hung Tai-Ho TH Ambudkar Suresh V SV
International journal of molecular sciences 20191229 1
Multidrug resistance caused by the overexpression of the ATP-binding cassette (ABC) proteins in cancer cells remains one of the most difficult challenges faced by drug developers and clinical scientists. The emergence of multidrug-resistant cancers has driven efforts from researchers to develop innovative strategies to improve therapeutic outcomes. Based on the drug repurposing approach, we discovered an additional action of TMP195, a potent and selective inhibitor of class IIa histone deacetyla ...[more]