Ontology highlight
ABSTRACT:
SUBMITTER: Cluzeau T
PROVIDER: S-EPMC6981810 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Cluzeau Thomas T Furstoss Nathan N Savy Coline C El Manaa Wejdane W Zerhouni Marwa M Blot Lauriane L Calleja Anne A Dufies Maeva M Dubois Alix A Ginet Clemence C Mounier Nicolas N Garnier Georges G Raynaud Sophie S Rohrlich Pierre Simon PS Peterlin Pierre P Stamatoullas Aspasia A Chermat Fatiha F Fenaux Pierre P Jacquel Arnaud A Robert Guillaume G Auberger Patrick P
International journal of molecular sciences 20191225 1
Myelodysplastic syndrome (MDS) defines a group of heterogeneous hematologic malignancies that often progresses to acute myeloid leukemia (AML). The leading treatment for high-risk MDS patients is azacitidine (Aza, Vidaza<sup>®</sup>), but a significant proportion of patients are refractory and all patients eventually relapse after an undefined time period. Therefore, new therapies for MDS are urgently needed. We present here evidence that acadesine (Aca, Acadra<sup>®</sup>), a nucleoside analog ...[more]