Ontology highlight
ABSTRACT:
SUBMITTER: Zuccarini G
PROVIDER: S-EPMC6982252 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Zuccarini Giulia G D'Atri Ilaria I Cottone Erika E Mackie Ken K Shainer Inbal I Gothilf Yoav Y Provero Paolo P Bovolin Patrizia P Merlo Giorgio Roberto GR
International journal of molecular sciences 20191225 1
The G protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R), and their endocannabinoid (eCBs) ligands, have been implicated in several aspects of brain wiring during development. Here we aim to assess whether interfering with CB1R affects development, neuritogenesis and pathfinding of GnRH and AgRP neurons, forebrain neurons that control respectively reproduction and appetite. We pharmacologically and genetically interfered with CB1R in zebrafish strains with fluorescently labele ...[more]