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Neurotoxicities associated with checkpoint inhibitors: Two case reports and a review of the literature.


ABSTRACT: We report a case of nivolumab-induced delayed-onset aseptic meningitis and a case of limbic encephalitis and peripheral nerve palsy with toxicity relapse 6 months after initial presentation. The atypical presentations contribute to our knowledge of these rare events and reinforce the necessity for vigilant monitoring and a multidisciplinary treatment approach.

SUBMITTER: Cordes LM 

PROVIDER: S-EPMC6982490 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Neurotoxicities associated with checkpoint inhibitors: Two case reports and a review of the literature.

Cordes Lisa M LM   Davarpanah Nicole N NN   Reoma Lauren B LB   Gasmi Billel B   Quezado Martha M   Khan Omar I OI   Nath Avindra A   Apolo Andrea B AB  

Clinical case reports 20191126 1


We report a case of nivolumab-induced delayed-onset aseptic meningitis and a case of limbic encephalitis and peripheral nerve palsy with toxicity relapse 6 months after initial presentation. The atypical presentations contribute to our knowledge of these rare events and reinforce the necessity for vigilant monitoring and a multidisciplinary treatment approach. ...[more]

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