Ontology highlight
ABSTRACT:
SUBMITTER: Marquez E
PROVIDER: S-EPMC6982814 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Márquez Edgar E Mora José R JR Flores-Morales Virginia V Insuasty Daniel D Calle Luis L
Molecules (Basel, Switzerland) 20191219 1
The antileukemia cancer activity of organic compounds analogous to ellipticine representes a critical endpoint in the understanding of this dramatic disease. A molecular modeling simulation on a dataset of 23 compounds, all of which comply with Lipinski's rules and have a structure analogous to ellipticine, was performed using the quantitative structure activity relationship (QSAR) technique, followed by a detailed docking study on three different proteins significantly involved in this disease ...[more]