Ontology highlight
ABSTRACT:
SUBMITTER: Mojzych M
PROVIDER: S-EPMC6982861 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Mojzych Mariusz M Bernat Zofia Z Karczmarzyk Zbigniew Z Matysiak Joanna J Fruziński Andrzej A
Molecules (Basel, Switzerland) 20200105 1
A series of new pyrazolo[4,3-<i>e</i>][1,2,4]triazine acyclonucleosides <b>2</b>-<b>5</b> and <b>8</b> were prepared and evaluated for their anticancer activity against human cancer cell lines (MCF-7, K-562) and CDK2/E, as well as Abl protein kinases inhibitors. Lipophilicity of the compounds was determined using C-18 and immobilized artificial membrane (IAM) chromatography. In order to confirm the molecular structures and synthesis pathway of new acyclonucleosides, X-ray analysis was performed ...[more]